MODERN TECHNOLOGICAL SOLUTIONS
MODERN TECHNO-LOGICAL SOLUTIONS
About us
7
Scientific applicants
30+
Patents
100+
Scientific technology and production competences
300+
Scientific articles and publications
About us
Baltengineering is a technological design and engineering company. The company was created to develop lab, pilot and production technologies, “turnkey” industrial solutions, as well as concept, basic and detailed design projects for pharmaceutical, food and other chemical related industries.
A specific occupation of the company is the development of microreactor technologies, the design and delivery of automated microreactor systems.
7
Scientific applicants
30+
Patents
100+
Scientific technology and production competences
300+
Scientific articles and publications
The company has an experienced and highly qualified personnel in the development of chemical synthesis technologies and analytical methods, as well as project design of lab and production facilities.
Baltengineering was established in 2018 and is within of the Baltros Group.“Baltengineering” is a resident of Special Economic Zone in Saint-Petersburg. The company has a valid membership for project design in certain construction self-regulation agency.
01
Who we are
02
Our competencies
03
Our strategy
Activities
01
TECHNOLOGICAL ENGINEERING
- Technical specifications development
- URS for technological equipment
- Technology transfer from lab to production
- Turnkey transfer of chemical technologies
- SOP development
- Starting regulation development
- Project concept design development
- Project basic and detailed design (3-D) development
- Personnel training
02
R&D SOLUTIONS
- Scientific/Patent research
- Studies of known methods
- Microreactor and traditional methods development
- Lab synthesis methods development
- Finishing stages development
- Lab/Production regulation documentation development
- Quality Assurance development
- Analytical methods development
- Validation of analytical methods
- Balance sheet and cost estimation
03
AVAILABLE MICRO‑REACTOR LAB INFRASTRUCTURE
- Flow reactors Miprowa®, Lonza Flow Plate®, ART® platform
- Flow reactors are based on Modular MicroReaction System (MMRS) by Ehrfeld Mikrotechnik
- Flexible MMRS allows to construct various flow systems from more than 60 individual modules for a broad range of specific reactions
ADVANTAGES OF FLOW SYNTHESIS METHODS
- Precise control of the technological parameters: temperature, pressure, reaction time, mixing and stoichiometry
- Rapid mixing. Best mass transfer. Totally different hydrodynamics compared to traditional synthesis in batch reactors
- Extremely rapid heat distribution between coolant and reaction compound
- Less impurities due to fast heat exchange, precise mixing control and exact residence time inside flow reactor
- Enhanced safety. Synthesis takes place only in a reaction cell with a very small volume. Chemical process can be stopped immediately
- Multi-stage synthesis without intermediate isolation of semi products
- Good scalability of chemical processes with saving of all the technological parameters and product quality
Our key competences
Our key competences are in the field of developing chemical synthesis and analytical technologies from lab to pilot and then to production level -both for traditional batch and flow processes
20%
R&D and intellectual property
30%
Chemical technology
10%
Quality assurance
25%
Engineering
15%
Marketing and Economics
How it works
01
PHASE ONE
Does flow technology work for the product or process?
We examine specific product or process for the applicability of flow chemical reaction
- Studies of known methods
- Patent research
- Own experience in applicability of new technological platform
We test the reaction whether it fits new technological platform
- Necessary ingredients and analytics supplies
- Lab experiments to test the reaction
- Agreement with a client over most promising chemical synthesis design
Phase one outcomes
- Lab protocols
- Lab samples
- Necessary analytics
- Preliminary report about applicability new technological platform for the reaction or product
02
PHASE TWO
Does flow technology have economic advantages over traditional chemical synthesis?
Lab Level technology development
- Avoiding or reducing impurities
- Increasing quality and quantity parameters of the product
- Meeting desired regulation requirements for the product
- Finishing stages development
Balance sheet estimation
- List of necessary ingredients and analytics
- Cost and availability of ingredients estimation
- Balance estimation and market price comparison
Phase two outcomes
- Complete lab recipe for the chemical process or technology
- Lab samples of the product
- Description of analytical methods
03
PHASE THREE
What is the cost of implementing flow technology?
Technical evaluation of pilot or production levelflow process implementation
- Lab recipe and desired productivity are submitted to the producer of the equipment
- Concept design of the production unit
- List of all peripheral equipment with technical description
Technology development meeting clientand regulation needs
- Finishing stages development and description
- Analytical methods development for all ingredients, semi-products and final product
Phase three outcomes
- Process definition documents
- Concept design of the project
- Business plan and financial model of the project
- Technical data for basic and detailed project design
- Complete balance sheet with economic value and cost estimation
04
PHASE FOUR
How to scale up chemical process from lab to pilot and production?
Scaling up the technology
- Scaling up and optimization from lab to pilot and production level
Engineering of the production unit or production site/plant
- Getting technical data for all the equipment – flow reactors and peripheral equipment
- Basic and detailed design (3D) of the production unit or production site/plant
- Detailed balance sheet with cost estimation of implementing flow technology into production
Phase four outcomes
- Basic or detailed design (3-D) of production unit or site/plant
- Verification of implementation cost of the project
05
PHASE FIVE
How to transfer flow technology into production and train personnel?
Technology transfer to client production site
- Development of all process documentation
- Analytical methods transfer
- On-site technology transfer
- On-site personnel training
- Training personnel at our Lab facility
- Master control of all construction and engineering services by other suppliers
Phase five outcomes
- Implementation of new flow technology platform
- Mastering new knowledge to achieve strategic competitive advantage
Projects
Pharmaceutical Plant “Baltpharma” LLC
Goals and objectives of the project:
Design of the API Plant
More than 12 thousand square meters.
Technical characteristics of the project:
Design of the API Plant
A wide range of products, including highly active APS.
Types of work / services
- «Technological solutions» stage P.
- Development of technical specifications for technological equipment.
- Working design in 3D.
- Calculation of categories for fire and explosion hazard.
- Automation of technological solutions.
Life Sciences Park
Goals and objectives of the project:
Design of an R&D center with an area of more than 500 square meters for biological and chemical synthesis technologies development
Finished dosages drugs and food additives development
Genetic test systems development, analytical methods
Quality assurance systems development.
Types of work / services
- «Technological solutions» stage P.
- Development of technical specifications for technological equipment.
- Working design in 3D.
- Calculation of categories for fire and explosion hazard.
- Development of ventilation and air conditioning concepts.
Analytical and chemical labs of Baltpharma company
Goals and objectives of the project:
Design of analytical and chemical laboratories for API synthesis technologies development.
Analytical methods development and quality control.
Types of work / services
- «Technological solutions» stage P.
- Development of technical specifications for technological equipment.
- Working design
- Calculation of categories for fire and explosion hazard.
- Development of ventilation and air conditioning concepts.
Our team
Our key competences are in the field of developing chemical synthesis and analytical methods. Transfer from lab to pilot and then to production level - both for traditional batch and flow processes.
Roman Novikov
Ph.D. in organic chemistry, R&D Director
R&D AND INTELLECTUAL PROPERTY
- Lab synthesis development
- Flow chemistry methods development (Ehrfeld Mikrotechnik)
- Organic chemistry of small molecules
- NMR, IR, UV, HPLC, GC, GC-MS, CD
Vladimir Sakharov
PhD in chemistry, Production Director
CHEMICAL TECHNOLOGY
- Development, transfer and industrial production of APIs and FDF
- GMP certification and implementation
- Technological documentation (SOPs, specifications, technological instructions, production protocols)
- Validation of engineering systems and technological equipment (IQ, OQ, PQ)
- Validation of the production process, validation of cleaning of technological equipment
Alexey Nirman
Quality Assurance Director Pharmaceutical quality assurance system
QUALITY ASSURANCE
- Audits of partners and regulators. GMP and ISO certification
- Analytical lab management
- Validation of automated environment monitoring systems, laboratory equipment (IQ, OQ, PQ), validation of the production process, cleaning validation of technological equipment
- Analytical methods of quality control (NMR, IR, UV, HPLC, GC, GC-MS)
Dmitriy Yurochkin
Head of Strategic Planning Department
ECONOMICS AND PROJECT MANAGEMENT
- Product portfolio development, strategic analysis
- Regulatory Affairs
- Government relations (GR)
- Business plan and financial models development
- Feasibility studies
- Sales Promotion
Nadezchda Grigorevskaya
Head of Project Department
ENGINEERING
- Lab Project design
- Industrial Project design
- Concept, basic and detailed Project design
Contacts
Dr. Alexey Smirnov
General director
Saint Petersburg, Road to Kamenka, 74, lit. A, room 202
